Erschienen ist er im Februar 2010 in der Zeitschrift Magnetic Resonance in Medicine, Vol. 63, Teil 2, Seiten 269-274.
High-resolution magic-angle spinning has become a valuable tool to study biologic samples; however, there are only a few high-resolution magic-angle spinning methodologies that have been explored specifically to deal with small semisolid biomaterials such as tissues. Here, we report a novel high-resolution 1H NMR spectroscopic approach using magic-angle coil spinning. We demonstrate its potential for intact tissues by combining a resonant microcoil with a large-volume commercial magic-angle spinning rotor, where the microcoil offers incredible sensitivity and the large-volume magic-angle spinning rotor provides stable slow magic-angle spinning. This approach provides high-resolution spectra with high sensitivity and the preservation of living biologic specimens for an accurate chemical analysis.
Die Autoren sind Mitglieder des Commissariat à l'Énergie Atomique Saclay, in Gif-sur-Yvette, Frankreich.
Online abrufbar ist der Artikel über DOI 10.1002/mrm.22231.
